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Antidepressants

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24 Antidepressants found

 ATCGroupadCthCtoxT1/2FdminDDDdmaxeqprelackidoldCOPDrenhepsedcarszcvaAChfergyndkhaeDMkgkg+kg-QTgenetics
AgomelatineN06AX22otheroral1.552536875410856611811115111112CYP1A2 (90%) and CYP2C9 (10%) substrate, CYP2C19
AmitriptylineN06AA09TCAoral100-300400154075538812881066681022124101001086(CYP1A2, CYP2D6, CYP2C19); CYP2C9 substrate
BupropionN06AX12NDRIoral20-503100378530056441281068862101281210010212CYP2B6 and CYP2C9 (8/9) substrate
CitalopramN06AB04SSRIoral40-200400-6003680-100206686148102101066108836410010626CYP2C19 (major 60%), CYP2D6 (minor) and CYP3A3/4 (minor, 30%) substrate; CYP2D6 (very weak/nil) and CYP3A3/4 (weak) inhibitor
ClomipramineN06AA04TCAoral200-400 (sum)60021501006646268106101068108813210100866CYP1A2, CYP2C19, CYP2D6
DosulepinN06AA16TCAoral40-4007501930150638714881066688321328301066CYP1A2, CYP2C19, CYP2D6
DoxepinN06AA12TCAoral100-2504001613-451006886128101066661023134880826CYP1A2, CYP2C19, CYP2D6
DuloxetineN06AX21SNRIoral12.530-80608810624101021010361086616808661CYP1A2, CYP2D6
EscitalopramN06AB10SSRIoral10-1004003080106685148828826816224822224CYP2C19
FluoxetineN06AB03SSRIoral5001500-20001687220681412882101062883164808116CYP2C9, CYP2C19, CYP2D6 and CYP3A3/4 substrate and inhibitor
FluvoxamineN06AB08SSRIoral50-25050018531006626128102101062833664822221CYP1A2 (partly), CYP2C19, CYP2D6 (partly) and CYP3A3/4 substrate; CYP1A2 (potent), CYP2C9, CYP2C19, CYP2D6 (very weak) and CYP3A3/4 (moderate) inhibitor
HypericumN06AX25otheroral, IV371453820681101000830018603200unknown
ImipramineN06AA02TCAoral150-350400-6001494-96100661812886666810333321022866CYP2D6
MaprotilineN06AA21otheroral100-4005004366-70100368816810686661022621880864CYP2D6
MianserinN06AX03NaSSAoral40-1253004020603686266101011381012122100882CYP2D6 and CYP3A3/4 substrate
MirtazapineN06AX11NaSSAoral50-300200305030568286610106638106163410100661CYP1A2 (partly), CYP2D6 (minor) and CYP3A3/4 (partly) substrate; CYP1A2 (very weak) and CYP2D6 (very weak/nihil) inhibitor
MoclobemideN06AG02RIMAoral1500-25005000-8000360-8030056822281021121010221148032101CYP1A2, CYP2C19 (major) and CYP2D6 inhibitor; CYP2C19 (major) substrate
NortriptylineN06AA10TCAoral50-150250365075661612866666810311341080826CYP2D6
ParoxetineN06AB05SSRIoral10-75350245020868614882101032863364880226CYP2D6
PhenelzineN06AF03MAO-Ioral-1.580-906056107261086101061081136688010101CYP2E1
SertralineN06AB06SSRIoral75-3004002622-3650662212810210106210108334822226CYP3A3/4 substrate (inhibitor weak); CYP1A2, CYP2C19 and CYP2D6 inhibitor (weak)
TranylcypromineN06AF04MAO-Ioral2502.550103688161086883108111168008101CYP2A6, CYP2C19, CYP2D6
TrazodoneN06AX05otheroral800-1600200076530038106248101062381068662880886CYP2D6 and CYP3A4 substrate
VenlafaxineN06AX16SNRIoral250-7501000540-451005884148821010621088111822864CYP2D6 substrate, CYP3A3/4 substrate and very weak inhibitor