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Alprazolam

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alprazolam
Type benzodiazepine
Group benzodiazepine
links
ATC-code N05BA12
CAS-number 28981-97-7
Medscape 342896
PubChem 2118
PubMed alprazolam
DailyMed 5816
Drugs.com alprazolam
drugbank APRD00280
Kompas (nl) alprazolam
Wikipedia alprazolam
more info
DDD 1mg [1]
Dmax 3mg [2]
Cth 20-40μg/L [3]
Ctox 75μg/L [4]
EQ-dosage 10[5] diazepam
T1/2 13.5h [2][6]
metabolites 8[2][7][8]
bioavailability 80%[7]
administration oral[8]
tablets 0.25,0.5,1,2,3 mg [8]
Price/day 0 [9]

alprazolam is a benzodiazepine in the group benzodiazepine.


Caution area Value Ref Description
Lactation 8 [10] Unsafe and possibly harming
Pregnancy 6 [7][8] high risk - C - suspected to cause reversible damage, but no malfunctions
Diabetes mellitus 1 [11] no influence on diabetes - safe
Hepatic insufficiency 8 [7] Unsafe with mild hepatic impairment (Child-Pugh classification A - monitoring required)
Children 2 [12] applicable - not registered for pediatric use, but well studied
Elderly 6 [2][8] average safety - adapt dosage
Dementia 8 [6] strong influence on cognition
Chronic Obstructive Pulmonary Disease 8 [2] unsafe - adapt dosage or substitute drug
Hypertension 1 safe - occurrence extremely rare (case-report)
Hypotension 8 [8] common (between 1 in 10 and 1 in 100 patients: 1% - 10%)
Heart failure 2 [13] weak influence on HF - rather safe, monitoring recommended
Long QT-syndrome 1 [14] no prolongation of QTc-interval - safe - Arizona Scale - not listed
Seizures 6 [10] uncommon (between 1 in 100 and 1 in 1,000 patients: 0,1% - 1%)
Cerebrovascular accidents 2 [13] weak influence on CVA - safe, monitoring recommended
Renal insufficiency 2 [7] generally safe - unsafe when MDRD < 10 (end stage renal disease (ESRD))
Dyskinesia 8 [8][15] common (between 1 in 10 and 1 in 100 patients: 1% - 10%)
Movement disorders 8 [8] common (between 1 in 10 and 1 in 100 patients: 1% - 10%)
Haematology 1 [15] occurrence extremely rare (case-report)
Anticholinergic effects 10 [8] very common (over 1 in 10 patients: > 10%)
Male sexual dysfunction 8 [8] common (between 1 in 10 and 1 in 100 patients: 1% - 10%)
Female sexual dysfunction 8 [8] common (between 1 in 10 and 1 in 100 patients: 1% - 10%)
Traffic 10 [7][16] severe influence (category III) >0,8 g/l (>0,8‰)
Weight 10 [8] very common (over 1 in 10 patients: > 10%)
Weight gain 3 [8] weight gain is uncommon (less than 1 in 1000 patients: <1%)
Weight loss 0 unknown/unverified
Photosensitivity 0 unknown/unverified
Sedation 10 [8] very common (over 1 in 10 patients: > 10%)
Poor CYP2D6 metabolizer 0 unknown/unverified
Ultra rapid CYP2D6 metabolizer 0 unknown/unverified
Poor CYPC19 metabolizer 0 unknown/unverified
Ultra rapid CYP2C19 metabolizer 0 unknown/unverified